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2 edition of Glycosidase inhibition studies. found in the catalog.

Glycosidase inhibition studies.

Robert A. Field

Glycosidase inhibition studies.

by Robert A. Field

  • 65 Want to read
  • 21 Currently reading

Published by University of East Anglia in Norwich .
Written in English


Edition Notes

Thesis(Ph.D), University of East Anglia, School of Chemical Sciences, 1989.

ID Numbers
Open LibraryOL13925157M

The controlled inhibition of glycosidases has potential for the treatment of many diseases such as diabetes, viral infections, and cancer. The synthesis of potential inhibitors of the enzyme human maltase glucoamylase (MGA) that catalyzes the breakdown of glucose-containing oligosaccharides, and hexosaminidase enzymes that cleave the ß. Bilal Ahmad Mir, M Amin Mir, Shalini Upadhay (): Inhibition of Alpha Amylase and Alpha Glycosidase Enzymes by Various Earth Worm Extracts. Biomedical and Pharmacology Journal. 11(3) Neha Kapoor Gambhir L and Saxena S (): Secondary Structure prediction of ITS rRNA region and Molecular phylogeny: an integrated approach for the.

The structures of ursolic acid and oleanolic acid related compound, including natural products and synthetic derivatives of ursolic acid and oleanolic acid, were identified by physical and spectral analyses, or literature data. The inhibitory activity of the triterpene compounds against α-glycosidase were evaluated. The in vitro results showed that the test pentacyclic triterpenes Author: Chen Lei, Yang XiaoSheng, Yang Juan, Ye LinHu, Hao XiaoJiang.   Anti-glycation effect and the α-amylase, lipase, and α-glycosidase inhibition properties of a polyphenolic fraction derived from citrus wastes Fernandes et .

3-OH-Aze 3 has only been prepared by oxidation of Aze 1 by proline hydroxylases. The formation of trans,transhydroxyhydroxymethyl-l-Aze 4 from d-glucose was the first chemical synthesis of an unprotected 3-OH-Aze 3. Compound 3 is a ring-contracted analogue of the dihydroxyproline 5. The roles of 2-oxoglutarate (2OG)-dependent prolylhydroxylases in eukaryotes include Cited by: Abstract. Alkaloids which are inhibitors of glycosidases are now believed to be widespread in plants and microorganisms. Those isolated to date carry several hydroxyl substituents on a ring in a configuration that suggests a structural resemblance to by:


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Glycosidase inhibition studies by Robert A. Field Download PDF EPUB FB2

Jun Hiratake, Kanzo Sakata, in Methods in Enzymology, Publisher Summary. Glycosidases are involved in a number of important biological processes, such as intestinal digestion, posttranslational modification of glycoproteins, and the lysosomal catabolism of glycoconjugates.

The inhibitors of glycosidases act as useful tools to understand the biological function of. Design, synthesis and glycosidase inhibition studies of novel triazole fused iminocyclitol-δ-lactams synthesis and glycosidase inhibition studies of novel triazole fused iminocyclitol-δ-lactams V.

Santhanam, books or book chapters) do not need to formally request permission to reproduce material contained in this article provided that. A new synthetic strategy has been devised to access a variety of polyhydroxylated piperidines belonging to the azasugar class of glycosidase inhibitors.

The key precursor (3aR, 7aR)benzyl-2,2-dimethylmethylenehexahydro[1,3]dioxo[4,5-c]pyridine is obtained by photoinduced electron transfer (PET) cycliza. Glycosidase inhibitors are proving to be useful tools for research dealing with GSL lysosomal storage diseases, and such inhibitors may prove to be valuable in the therapy of these diseases as well.

GSL are ubiquitous components of all the cellular membranes of eukaryotic cells, and some different glycolipid structures have now been identified. Although these GSLs. 50% alpha amylase inhibition activity at the mentioned concentrations.

Percent alpha amylase and alpha glucosidase inhibition of the four plants extracts was plotted as a function of concentration in comparison with acarbose as shown in Figure 1 Cited by: Among the ten N-acetylamino pyrrolidine analogues, only compounds with 2,5-dideoxy-2,5-imino-d-mannitol (DMDP) and pochonicine (1) configurations showed potent inhibition of β-N-acetylhexosaminidases (β-HexNAcases); while 1-amino analogues lost almost all their inhibitions towards the tested enzymes.

The multivalent Glycosidase inhibition studies. book in glycosidase inhibition is a new topic in glycoscience that has emerged few years ago with the discovery of neoglycoclusters displaying strong binding enhancements over.

Preliminary glycosidase inhibition studies indicated that DAJNAc is the strongest competitive inhibitor of human placenta b-GlcNAcase (bhexosaminidase) among the.

Cross-metathesis (CM) and Keck asymmetric allylation, which allows access to defined stereochemistry of a remote side chain hydroxyl group, are the key steps in a versatile synthesis of broussonetine M (3) from the d-arabinose-derived cyclic nitrone By a similar strategy, ent-broussonetine M (ent-3) and six other stereoisomers have been synthesized, respectively, Cited by: 1.

Inhibition of these glycosidases can have profound effects on quality control, maturation, transport, and secretion of glycoproteins and can alter cell–cell or cell–virus recognition processes. This principle is the basis for the potential use of glycosidase inhibitors in viral infection, diabetes and genetic by: 4.

Synthesis and Glycosidase Inhibition Studies of 5-Methyl-Substituted Tetrahydroxyindolizidines and -pyrrolizidines Related to Natural Hyacinthacines B Daniele Martella, Francesca Cardona, Camilla Parmeggiani, Francisco Franco, Juan A.

Tamayo, Inmaculada Robina, Elena Moreno-Clavijo, Antonio J. Moreno-Vargas, Andrea GotiCited by: Title:Diels-Alder Cycloaddition in the Synthesis of 1-Azafagomine, Analogs, and Derivatives as Glycosidase Inhibitors VOLUME: 12 ISSUE: 14 Author(s):Daniela A.L.

Salgueiro, Cristina E.A. Sousa, A. Gil Fortes and M. Jose Alves Affiliation:Departamento de Quimica, Universidade do Minho, Campus de Gualtar, Braga, Portugal. Cited by: 2. Abstract: The inhibitory activities against glycosidases of synthetic thiasugars, the ring sulfur analogs of carbohydrate, were surveyed with a special emphasis on our own studies.

5-Thio-L-fucose, the ring sulfur analog of L-fucose, was the first thiopyran that shows a Ki value in the micromolar range against a by: @article{osti_, title = {Specific mechanism-based glycosidase inhibitors as chemoprotectants against ricin toxicity.

Final report, 1 June August }, author = {Stohs, S J}, abstractNote = {Ricin is prototypical of many protein toxins, and is one of the most toxic compounds known to man. At the present time, no specific treatment is available for.

The treatment of glycosphingolipid storage diseases by synthesis inhibition was first proposed 40 years ago as an alternative approach to enzyme replacement therapy. We have pursued this strategy through the rational design of potent and selective inhibitors of glucosylceramide synthase, the first Cited by: A novel and challenging approach for the construction of multivalent iminosugar architectures directly on calixarene scaffolds is presented, which exploits multiple cycloaddition reactions of a carbohydrate-derived nitrone on diversely functionalized calix[4]arenes.

Regardless of the 4-fold reiteration on a single calixarene, the reactions take place with high regio- and stereoselectivity Cited by:   It is likely that these differences in extract composition explain the differences in of α-amylase and α-glucosidase inhibition observed in the present paper.

Previous studies have determined several key structural features needed for monomeric flavonoids to inhibit α-amylase and α-glucosidase activ 22, 24, Cited by: contributing to a higher inhibition activity.[30] In the large group of glycosidase inhibitors, synthetic studies have already been highlighted in several classes,[] e.g.

for pyrrolidines,[34,35] piperidines,[36,37] bicyclic compounds such as indolizidines[38] and. Hypoglycemic effect was also tested by the studies on inhibition effects on α-amylase and α-glucosidase.

In addition, through Linerweaver-Burk plots analysis that the inhibitory type of black tea polysaccharides effect on α-glycosidase was determined. Ultrasonic treatment ultrasonic treatment Subject Category: Techniques, Methodologies and Cited by: 1. @article{osti_, title = {{sup 1}H NMR spectroscopic studies establish that heparanase is a retaining glycosidase}, author = {Wilson, Jennifer C., E-mail: @ and Laloo, Andrew Elohim and Singh, Sanjesh and Ferro, Vito}, abstractNote = {Highlights: •{sup 1}H and {sup 13}C NMR chemical shifts of fondaparinux were fully assigned by 1D and 2D NMR.

The book will be a generally interesting source of information for chemists and biochemists.' (from the foreword by H. Paulsen). A table which lists over glycosidase inhibitors, more than enzymes with citations and over invaluable sets of data completes the book.An enzyme inhibitor is a molecule that binds to an enzyme and decreases its binding to enzymes' active sites, inhibitors reduce the compatibility of substrate and enzyme and this leads to the inhibition of Enzyme-Substrate complexes' formation, preventing the catalyzation of reactions and decreasing (at times to zero) the amount of product produced by a reaction.

Pesticides cause pollution by remaining in water, soil, fruits and vegetables for a long time and also reach human through the food chain. It was thought that some pesticides used in agriculture could adversely affect the antioxidant enzyme system and the minimum inhibition values were studied.

glutathione s-transferase (GST), an important antioxidant enzyme, Cited by: 4.